Vornado Realty Trust is poised to join the city’s Great Casino Sweepstakes by rolling the dice on a gambling den near Madison Square Garden, The Post has learned.

The city’s second-largest commercial landlord is weighing whether to bid on a prized casino license at the site of the soon-to-be demolished Hotel Pennsylvania, a source close to the situation told The Post.

The shuttered hotel – where luminaries from Harry Houdini to Fidel Castro once stayed – sits squarely in Gov. Kathy Hochul’s proposed, nine-block redevelopment around a “new” Penn Station. Vornado is designated to develop five of eight office sites, where some buildings will be demolished and tenants evicted.